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Protein kinases of the human malaria parasite Plasmodium falciparum: the kinome of a divergent eukaryote

BMC Genomics · 2004 · Vol. 5(1) · pp. 79–79
Pauline N. WardLeila EquinetJeremy C.L. PackerChristian Doerig

Abstract

The considerable phylogenetic distance between Apicomplexa and other Eukaryotes is reflected by profound divergences between the kinome of malaria parasites and that of yeast or mammalian cells.

Malaria Research and ControlMosquito-borne diseases and controlTrypanosoma species research and implicationsKinomeBiologyEukaryoteMalariaPlasmodium falciparumPlasmodium (life cycle)Parasite hostingKinaseVirologyEvolutionary biology

MeSH terms

AnimalsEukaryotic CellsHumansPhylogenyPlasmodium falciparumProtein KinasesGenetic VariationMalaria, Falciparum

Funding

  • U.S. Department of Defense
  • Burroughs Wellcome Fund
  • Wellcome Trust
  • Imperial College London
  • Institut National de la Santé et de la Recherche Médicale
  • Ministère de la Défense
  • Délégation Générale pour l'Armement
  • National Institutes of Health
  • National Institute of Allergy and Infectious Diseases
Citations
508
FWCI
21.22
field-weighted impact
References
87
Percentile
100%
vs. same field & year
Citations per year
References
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European Journal of Biochemistry · 2001 · 650 citations
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Science · 2002 · 8,071 citations
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Nature Genetics · 2000 · 43,975 citations
Protein kinases — the major drug targets of the twenty-first century?
Nature Reviews Drug Discovery · 2002 · 2,171 citations
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Nucleic Acids Research · 2002 · 14,220 citations
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Bioinformatics · 1998 · 5,777 citations
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