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Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality

Annals of Internal Medicine · 2005 · Vol. 142(1) · pp. 37–46
Edgar R. MillerRoberto Pastor‐BarriusoDarshan DalalRudolph A. RiemersmaLawrence J. AppelEliseo Güallar

Abstract

High-dosage (> or =400 IU/d) vitamin E supplements may increase all-cause mortality and should be avoided.

Antioxidant Activity and Oxidative StressVitamin C and Antioxidants ResearchRetinoids in leukemia and cellular processesMedicineDoseMeta-analysisClinical trialVitaminInternal medicineRelative riskRandomized controlled trialVitamin EObservational study

MeSH terms

AdultDose-Response Relationship, DrugHumansMortalitySensitivity and SpecificityVitamin ERandomized Controlled Trials as TopicDietary Supplements
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