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Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans

Genome biology · 2000 · Vol. 2(1) · pp. RESEARCH0002–RESEARCH0002

Ravi S. Kamath✉(University of Cambridge)Maruxa Martinez-Campos(Wellcome/Cancer Research UK Gurdon Institute)Peder Zipperlen(University of Cambridge)Andrew Fraser(Wellcome/Cancer Research UK Gurdon Institute)Julie Ahringer(University of Cambridge)

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Abstract

RNAi by feeding can provide significant information about the functions of an individual gene beyond that provided by injection. Moreover, it can be used for special applications for which injection or the use of mutants is sometimes impracticable (for example, titration, biochemistry and large-scale screening). Thus, RNAi by feeding should make possible new experimental approaches for the use of genomic sequence information.

CRISPR and Genetic Engineering Genetics, Aging, and Longevity in Model Organisms Insect Resistance and GeneticsRNA interferenceBiologyCaenorhabditis elegansGeneGeneticsRNA silencingPhenotypeRNALethal allele

MeSH terms

AnimalsEscherichia coliGenetic VectorsMicroinjectionsPhenotypeRNA, Double-StrandedTransfectionTransformation, GeneticCaenorhabditis elegansGenes, HelminthRNA, Helminth

Funding

Wellcome Trust

Citations

1,341

FWCI

9.64

field-weighted impact

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99%

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References

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

Nature · 1998 · 15,183 citations

THE GENETICS OF <i>CAENORHABDITIS ELEGANS</i>

Genetics · 1974 · 15,324 citations

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