articleTop 10% cited

Communication between Multiple Drug Binding Sites on P-glycoprotein

Molecular Pharmacology · 2000 · Vol. 58(3) · pp. 624–632

Catherine Martin✉(Hammersmith Hospital)G. Berridge(University of Oxford)Christopher F. Higgins(University of Oxford)Prakash Mistry(John Radcliffe Hospital)Peter Charlton(University of Oxford)Richard Callaghan(John Radcliffe Hospital)

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Drug Transport and Resistance Mechanisms Adenosine and Purinergic Signaling Pharmacological Effects and Toxicity StudiesP-glycoproteinBinding siteAllosteric regulationGlycoproteinATP-binding cassette transporterTransporterFunction (biology)Plasma protein bindingBiochemistryChemistry

MeSH terms

AcridinesAllosteric RegulationAnimalsBenzimidazolesBenzylidene CompoundsBinding, CompetitiveCell MembraneDrug InteractionsCricetinaeIsoquinolinesKineticsNicardipineQuinolinesRadioligand AssayTritium

Citations

415

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8.27

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98%

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References

Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells.

Molecular Pharmacology · 1988 · 414 citations

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

Annual Review of Biochemistry · 1993 · 3,504 citations

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