article Open AccessTop 1% cited
Randomised clinical trial: gut microbiome biomarkers are associated with clinical response to a low <scp>FODMAP</scp> diet in children with the irritable bowel syndrome
Alimentary Pharmacology & Therapeutics · 2015 · Vol. 42(4) · pp. 418–427
Bruno P. Chumpitazi✉(Baylor College of Medicine)Julia Cope(Baylor College of Medicine)Emily B. Hollister(Texas Children's Hospital)C.-M. Tsai(Baylor College of Medicine)Ann R. McMeans(Children's Nutrition Research Center at Baylor College of Medicine)Renato A. Luna(Texas Children's Hospital)James Versalovic(Texas Children's Hospital)Robert J. Shulman(Baylor College of Medicine)
Abstract
In childhood IBS, a low FODMAP diet decreases abdominal pain frequency. Gut microbiome biomarkers may be associated with low FODMAP diet efficacy. ClinicalTrials.gov identifier: NCT01339117.
Gastrointestinal motility and disordersDiet and metabolism studiesGut microbiota and healthIrritable bowel syndromeMedicineGastroenterologyInternal medicineFaecalibacterium prausnitziiAbdominal painCrossover studyMicrobiomeGut floraPlacebo
MeSH terms
Gastrointestinal MicrobiomeAdolescentChildDisaccharidesDouble-Blind MethodFemaleFermentationHumansMaleMonosaccharidesOligosaccharidesPolymersRNA, Ribosomal, 16SBiomarkersAbdominal Pain
Funding
- U.S. Department of Agriculture
- Mead Johnson Nutrition
- North American Society for Pediatric Gastroenterology, Hepatology and Nutrition
- National Institutes of Health
- NASPGHAN Foundation
- National Research Council Canada
- National Institute of Nursing Research
- National Institute of Diabetes and Digestive and Kidney Diseases
Citations
420
FWCI
28.96
field-weighted impact
References
55
Percentile
100%
vs. same field & year
Citations per year
References
Greengenes, a Chimera-Checked 16S rRNA Gene Database and Workbench Compatible with ARB
Applied and Environmental Microbiology · 2006 · 11,173 citations
Microbiome of prebiotic-treated mice reveals novel targets involved in host response during obesity
The ISME Journal · 2014 · 601 citations
QIIME allows analysis of high-throughput community sequencing data
Nature Methods · 2010 · 35,655 citations
Chimeric 16S rRNA sequence formation and detection in Sanger and 454-pyrosequenced PCR amplicons
Genome Research · 2011 · 3,523 citations
Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences
Nature Biotechnology · 2013 · 9,204 citations
Search and clustering orders of magnitude faster than BLAST
Bioinformatics · 2010 · 21,473 citations
Structure, function and diversity of the healthy human microbiome
Nature · 2012 · 11,749 citations
Metagenomic biomarker discovery and explanation
Genome biology · 2011 · 16,223 citations
Related articles
<i>Faecalibacterium prausnitzii</i> is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
Proceedings of the National Academy of Sciences · 2008 · 4,255 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.