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Abnormalities of maternal thyroid function during pregnancy affect neuropsychological development of their children at 25–30 months

Clinical Endocrinology · 2009 · Vol. 72(6) · pp. 825–829

Yuanbin Li✉Zhongyan Shan(Institute of Endocrinology)Weiping Teng(Institute of Endocrinology)Xiaohui YuYushu Li(Institute of Endocrinology)Chenling Fan(Institute of Endocrinology)Xiaochun Teng(Institute of Endocrinology)Rui Guo(Institute of Endocrinology)Wang Hong(Institute of Endocrinology)Jia LiYanyan ChenWeiwei WangMasauso ChawingaLi Zhang(China Medical University)Yang Liu(China Medical University)Yaru Zhao(China Medical University)Tianyi Hua(China Medical University)

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Abstract

Intellectual and motor development of children at 25-30 months of age is separately associated with abnormalities of maternal thyroid at 16-20 weeks gestation. Maternal subclinical hypothyroidism, hypothyroxinaemia or euthyroidism with elevated TPOAb titres were all statistically significant predictors of lower motor and intellectual development at 25-30 months.

Thyroid Disorders and Treatments Neonatal Health and Biochemistry Pregnancy and preeclampsia studiesMedicineSubclinical infectionEuthyroidThyroid peroxidaseInternal medicineEndocrinologyThyroid functionPregnancyAnti-thyroid autoantibodiesThyroid

MeSH terms

Developmental DisabilitiesChild, PreschoolCognitionFemaleHumansInfantMaleNeuropsychological TestsPregnancyPregnancy ComplicationsPregnancy Trimester, SecondPrenatal Exposure Delayed EffectsThyroid DiseasesThyroid Function TestsThyroid Gland

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Cited by

Management of Thyroid Dysfunction during Pregnancy and Postpartum: An Endocrine Society Clinical Practice Guideline