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A Novel Rabbit Model of Mild, Reproducible Disc Degeneration by an Anulus Needle Puncture: Correlation Between the Degree of Disc Injury and Radiological and Histological Appearances of Disc Degeneration

Spine · 2005 · Vol. 30(1) · pp. 5–14

Abstract

The needle puncture approach, using 16G to 21G needles, resulted in a reproducible decrease of disc height and magnetic resonance imaging grade. The ease of the procedure and transfer of the methodology will benefit researchers studying disc degeneration.

Spine and Intervertebral Disc PathologyMusculoskeletal pain and rehabilitationMedical Imaging and AnalysisMedicineMagnetic resonance imagingDegenerative disc diseaseIntervertebral discDegeneration (medical)Nuclear medicineRadiographyAnimal modelRadiologyPathology

MeSH terms

AnimalsArthrographyDisease Models, AnimalIntervertebral DiscIntervertebral Disc DisplacementMagnetic Resonance ImagingNeedlesRabbitsSeverity of Illness IndexWounds, StabReproducibility of Results

Funding

  • National Institutes of Health
Citations
713
FWCI
10.35
field-weighted impact
References
42
Percentile
99%
vs. same field & year
Citations per year
References
Autoimmunity to type II collagen an experimental model of arthritis.
The Journal of Experimental Medicine · 1977 · 1,596 citations
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A Novel Rabbit Model of Mild, Reproducible Disc Degeneration by an Anulus Needle Puncture: Correlation Between the Degree of Disc Injury and Radiological and Histological Appearances of Disc Degeneration · Scinovex