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The serotonin syndrome

American Journal of Psychiatry · 1991 · Vol. 148(6) · pp. 705–713
Harvey Sternbach

Abstract

The serotonin syndrome is a toxic condition requiring heightened clinical awareness for prevention, recognition, and prompt treatment. Further work is needed to establish the diagnostic criteria, incidence, and predisposing factors, to identify the role of 5-HT antagonists in treatment, and to differentiate the syndrome from neuroleptic malignant syndrome.

Electroconvulsive Therapy StudiesNeurotransmitter Receptor Influence on BehaviorCancer Treatment and PharmacologySerotonin syndromeSerotonergicMedicineSerotoninHyperreflexiaDiscontinuationNeuroleptic malignant syndromeTourette syndromePsychologyInternal medicine

MeSH terms

AdultAntidepressive AgentsBasal Ganglia DiseasesDepressive DisorderDrug InteractionsDrug Therapy, CombinationDyskinesia, Drug-InducedFemaleFluoxetineHumansMaleMonoamine Oxidase InhibitorsNeuroleptic Malignant SyndromeReceptors, SerotoninSerotonin
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