articleTop 10% cited
Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes
Journal of Controlled Release · 2015 · Vol. 217 · pp. 345–351
Norbert Pardi✉(University of Pennsylvania)Steven Tuyishime(University of Pennsylvania)Hiromi Muramatsu(University of Pennsylvania)Katalin Karikó(University of Pennsylvania)Barbara L. Mui(Acuitas Therapeutics (Canada))Ying K. Tam(Acuitas Therapeutics (Canada))Thomas D. Madden(Acuitas Therapeutics (Canada))Michael J. Hope(Acuitas Therapeutics (Canada))Drew Weissman(University of Pennsylvania)
RNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesRNA and protein synthesis mechanismsKineticsNucleosideChemistryMessenger RNANanoparticleBiochemistryNanotechnologyMaterials scienceGenePhysics
MeSH terms
AnimalsCells, CulturedDendritic CellsFemaleHumansKineticsLungMice, Inbred BALB CPhosphatidylethanolaminesPseudouridineRNA, MessengerTransfectionLuciferases, FireflyNanoparticlesHEK293 Cells
Funding
- Bill and Melinda Gates Foundation
Citations
999
FWCI
11.00
field-weighted impact
References
29
Percentile
99%
vs. same field & year
Citations per year
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References
mRNA-based therapeutics — developing a new class of drugs
Nature Reviews Drug Discovery · 2014 · 2,333 citations
Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA
Immunity · 2005 · 2,527 citations
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