Implication and characterization of nanostructured carriers loaded with naproxen sodium by solvent evaporation technique

Abstract

This research intends to formulate and develop a drug delivery system utilizing a nanostructure by means of the solvent evaporation method. An active pharmaceutical ingredient (API), naproxen sodium, has been selected for this study. It is expected that naproxen sodium loaded nanocarriers will create a synergistic pharmacological effect. Moreover, this method can help prevent irritation of the upper gastrointestinal tract mucosal lining since the drug won’t directly contact it. Additionally, the formulation may become safer, achieve better water solubility, have a quicker onset of action, or penetrate biological membranes more effectively. For the preparation of the drug, naproxen sodium needs to be dissolved in a suitable organic solvent along with a polymer, such as Eudragit L-100, and then combined with an aqueous phase that contains a suitable surfactant. Following that, drug-loaded nanocarriers are created by continuously evaporating the mixture. The generated particles were meticulously analyzed using scanning electron microscopy (SEM) to determine their dimensions, shapes, and morphology. Based on the results from the SEM analysis, the particle size was found to vary between 1 to 100 nm. The incorporation of drugs was observed to have no distinct impact on the size and structure of the nanocarriers.