Pharmacokinetics of marbofloxacin in sheep following intravenous administration

Abstract

The pharmacokinetics of marbofloxacin were investigated in sheep following single-dose intravenous administration at a dose rate of 2.0 mg/kg. The plasma concentration of marbofloxacin was assayed using an LC-MS/MS method. Following single dose intravenous administration of marbofloxacin at the dose rate of 2.00 mg/kg, the plasma concentrations of marbofloxacin > 0.04 µg mL-1 persisted for up to 24 hours post drug administration. The mean values of elimination rate constant, half-life, area under curve, mean residence time, and total body clearance were found to be 0.28 ± 0.07 h-1, 3.03 ± 0.51 h, 6.87 ± 1.08 µg·h/mL, 3.30 ± 0.78 h, and 0.39 ± 0.04 L/h/kg, respectively. The present study demonstrates that single intravenous administration of marbofloxacin in sheep at the dose rate of 2.0 mg/kg led to persistence of effective therapeutic concentration in sheep for a longer duration of time (up to 24 hours), so it can be effectively employed in the treatment of susceptible bacterial infections.