Optimization and in vitro evaluation of floating tablets of atenolol

Abstract

The present research work demonstrates that he combination of both hydrophilic and hydrophobic polymers successfully employed for formulating the sustained release matrix tablets of Atenolol. It is observed that optimum concentration of each of the polymer in combination was able to produce desired formulation which releases complete drug in 12 hours. The mechanism of drug release has observed the combined effect of diffusion and erosion for sustained drug release. So, the combination of both hydrophilic and hydrophobic retardant was suitable to produce the matrix tablet rather than using a single type of polymer. All the preformulation parameters showed acceptable flow properties. The evaluation of tablet like the thickness, diameter, hardness, friability, weight variation, disintegration time, drug content and in-vitro percentage drug release were carried out and the values were found to within IP limits.