Anti-inflammatory and analgesic activity of ethanolic extracts of Actinidia deliciosa and Vitis vinifera in experimental rodent model

Abstract

The present study was undertaken to evaluate the anti-inflammatory and analgesic activities of ethanolic extracts of Actinidia deliciosa and Vitis vinifera using experimental rodent models. Anti-inflammatory activity was evaluated using Complete Freund’s Adjuvant (CFA)-induced arthritis in Wistar rats, while analgesic activity was assessed using Eddy’s hot plate method in mice. Ethanolic extracts of A. deliciosa and V. vinifera were administered orally at a dose of 250 mg/kg. Indomethacin (2 mg/kg) served as the standard anti-inflammatory drug. CFA-induced arthritic rats showed significant joint swelling and reduction in body weight. Treatment with both plant extracts significantly reduced joint diameter and improved body weight compared to arthritic control animals (p