Efficacy of Dutasteride Intradermal Injection in The Treatment of Androgenetic Alopecia

Abstract

Background: Androgenetic alopecia, mostly influenced by genetic and hormonal determinants, is the predominant hair loss form in adults condition. Intradermal dutasteride represent effective localized and regenerative treatment alternatives with fewer systemic side effects. This study intended to assess the intradermal dutasteride injections efficacy in treating androgenic alopecia. Methods: This prospective randomized study was conducted on 15 male patients with AGA. All patients underwent full history taking, Comprehensive assessment to rule out systemic diseases, dermatological evaluation for androgenetic alopecia regarding site and severity according to Norwood-Hamilton classification. Results: There was significant clinical improvement 1 and 3 months after treatment. The maximum clinical improvement was noted at one-month post-treatment. The medication was well-tolerated, with no significant side effects noted.There was no significant correlation between maximum clinical improvement as well as age, while there was significant negative correlation between maximum improvement and disease duration in studied patients (P=0.005). Conclusions: Intradermal dutasteride injection was effective and safe for AGA treatment.