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Effect of isoprenaline on precontracted isolated pulmonary artery of goat
International Journal of Advanced Biochemistry Research · 2026 · Vol. 10(1) · pp. 471–475
S. Ilavarasan✉Meemansha SharmaMamta MeenaAnand Mohan MishraPravin Maruti MadabhaviManju GariShweta SinghRiya TalariyaAnshuk SharmaAneesha VaMadhu Chollenhalli LingarajuSubhashree ParidaThakur Uttam Singh
Abstract
The objective of the present study was to investigate the effect of isoprenaline on goat precontracted isolated pulmonary artery. Isoprenaline (10⁻⁹-10⁻³ M) elicited a concentration-dependent relaxation in histamine (10 µM) precontracted pulmonary arterial rings of goat with a maximal relaxation of 21.31±3.72% (n=6) and a pD2 of 7.82±0.24. Mechanical removal of the endothelium did not significantly modify the relaxant response with maximal relaxation. Pretreatment with propranolol (10 µM) attenuated the isoprenaline-mediated relaxation. Blockade of KATP channels with glibenclamide (10 µM) significantly (p
Nitric Oxide and Endothelin EffectsInfectious Aortic and Vascular ConditionsCardiac Ischemia and ReperfusionIsoprenalineGlibenclamidePropranololPulmonary arteryHistamineBlockadeVasodilation
Funding
- Indian Council of Agricultural Research
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