Formulation and evaluation of a novel transferosomal gel for enhanced transdermal delivery of resveratrol

Abstract

This study investigates the formulation and evaluation of a novel transferosomal gel designed to enhance the transdermal delivery of resveratrol, a potent polyphenolic compound known for its antioxidant, anti-inflammatory, and anticancer properties. Despite its therapeutic potential, resveratrol suffers from poor bioavailability and limited efficacy when administered via conventional routes, such as oral delivery. Transferosomes, which are ultra-deformable lipid vesicles, are utilized in this formulation to overcome the skin's natural barrier, allowing for improved drug permeation. In this study, transferosomes encapsulating resveratrol were prepared using the thin-film hydration method, followed by incorporation into a gel base to form a transferosomal gel. The transferosomal formulations were characterized for their physicochemical properties, including vesicle size, surface charge (zeta potential), and entrapment efficiency, to ensure stability and optimal performance. The gel formulation was optimized for viscosity, texture, and skin adhesion properties to enhance user comfort and drug delivery efficiency. The evaluation of the formulated gel included in vitro drug release studies, using Franz diffusion cells, to determine the release profile of resveratrol. Skin permeation studies were conducted on excised rat skin to assess the ability of the transferosomal gel to enhance the penetration of resveratrol into deeper layers of the skin. Additionally, stability studies were performed to determine the shelf-life and storage conditions required to maintain the gel's efficacy over time.