Comparative Study of Nebulized Dexmedetomidine vs Nebulized Lignocaine for Attenuation of Hemodynamic Response to Laryngoscopy and Endotracheal Intubation

Abstract

Background: Laryngoscopy and endotracheal intubation provoke transient but significant sympathoadrenal responses. This randomized comparative study evaluates nebulized dexmedetomidine (1 ?g/kg) versus nebulized lignocaine (1.5 mg/kg) for attenuation of hemodynamic responses to laryngoscopy and intubation. Methods: Sixty adult patients (ASA I-II) undergoing elective surgery were randomized to receive nebulized dexmedetomidine (n=30) or nebulized lignocaine (n=30) 15 minutes prior to induction. Heart rate (HR), systolic arterial pressure (SAP), diastolic arterial pressure (DAP) and mean arterial pressure (MAP) were recorded at baseline and at 1, 3, 5 and 10 minutes after tracheal intubation. Primary outcome was difference in HR and MAP after intubation. Statistical analysis used t-tests for group comparisons; p<0.05 considered significant. Results: Nebulized dexmedetomidine significantly attenuated increases in HR and arterial pressures compared with nebulized lignocaine at 1 and 3 minutes after intubation (p<0.05). Group means and statistical summary are presented in the Results section. Conclusion: Nebulized dexmedetomidine (1 ?g/kg) appears superior to nebulized lignocaine (1.5 mg/kg) in blunting the immediate hemodynamic response to laryngoscopy and intubation without clinically important adverse events