Protective efficacy of resveratrol against arsenic induced sub-chronic toxicity: A pathomorphological study in wistar rats

Abstract

The present investigation was undertaken to evaluate the pathomorphological alterations associated with arsenic-induced sub-chronic toxicity in Wistar rats and its amelioration with resveratrol. Thirty-six adult male Wistar rats were randomly divided into six groups (n=6). Group I served as normal control, Group II as disease control (NaAsO₂ @ 10 mg/kg b.wt. orally for 60 days), Group III received treatment same as Group II along with telmisartan (10 mg/kg b.wt. orally for 60 days) as a reference control group and Groups IV-VI received treatment same as Group II along with resveratrol at graded doses (4, 8, and 16 mg/kg b.wt. orally for 60 days). The disease control group exhibited a significant reduction (p