Pharmacological effects of Cathranthus Pussilus leaves extract on ovalbumin induced asthma in guinea Pigs

Abstract

Asthma is a chronic inflammatory disease of the respiratory tract in which the numerous immune cells, including eosinophils, neutrophils, macrophages, T-lymphocytes, mast cells and epithelial lining play key roles. The numerous anti-asthmatic drugs are available in modern medicine to treat asthma, but they have several disadvantages, including side effects and the cost variations, which compromise treatment compliance. The literature review reveals that traditional herbal medicines have good potential as alternative treatment and management for asthma. However, communities hesitated to use the traditional herbal medicines due to lack of established mechanism of action about their anti-asthmatic potential. The present aimed to show the potential effect of Catharanthus pusillus conferring protection against ovalbumin (OVA)-induced asthma model.