Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN): Overlap syndrome secondary to ciprofloxacin and Aceclofenac: A case report

Abstract

Background: Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN) is a life-threatening mucocutaneous reaction most commonly triggered by medications.A case of a 29-year-old male who developed SJS/TEN overlap syndrome following consumption of ciprofloxacin and aceclofenac. The patient presented with fever, extensive skin erosions, and mucosal involvement, including ocular and scrotal ulcers.Investigations: Clinical examination revealed widespread erythematous crusted lesions. Laboratory investigations showed mild leukocytosis and deranged liver function tests. Sputum culture confirmed Methicillin-Resistant Staphylococcus Aureus (MRSA) pneumonia. Skin biopsy was consistent with SJS/TEN overlap syndrome.Treatment: The patient was managed with systemic corticosteroids, intravenous immunoglobulin (IVIG), targeted antibiotic therapy, and comprehensive supportive care.Outcome: Patient showed gradual improvement with reduced skin erosions and stabilization of systemic symptoms, leading to successful discharge with specialized follow-up care.