Renal involvement in patients with visceral leishmaniasis

Abstract

Visceral leishmaniasis (kala-azar) is a chronic and potentially fatal parasitic disease. It has been determined that renal involvement can lead to glomerular and tubular dysfunction. This study aimed to assess renal function in Sudanese patients with visceral leishmaniasis by measuring plasma urea and creatinine levels Methods: A case control study was conducted at Gadarif Teaching Hospital in Eastern Sudan. Thirty patients with confirmed visceral leishmaniasis and twenty healthy matched controls were enrolled. Plasma levels of urea and creatinine were measured for all participants at enrollment, for the patient group measurements were repeated after treatment with sodium stibogluconate. Results: Plasma creatinine and urea levels were significantly higher (p