Effects of quercetin on meloxicam-induced haemato-biochemical alterations in male wistar rats

Abstract

The present study was carried out to evaluate the protective effects of quercetin (@ 50 & 100 mg/kg body weight) in meloxicam (@ 2.1 & 4.2 mg/kg body weight) induced haematological and biochemical alteration in Wistar rats (n = 56) for 28 days. In groups I to VII animals were administered with and respectively. There was a significant decrease in values of haemoglobin, packed cell volume, platelets, total erythrocyte count and significant increase in neutrophil count in group II and III (meloxicam @ 2.1 & 4.2 mg/kg) in comparison with control group (0.5 mL of carboxy methyl cellulose). Moreover, group treated with quercetin at dose rate of 100 mg/kg body weight. (groups V and VII) along different doses of meloxicam (2.1 mg/kg body weight. and 4.2 mg/kg body weight.) showed significant (p