Gene expression of CD70 in patients with acne vulgaris

Abstract

Background: Acne vulgaris is one of the most prevalent chronic inflammatory disorders of the pilosebaceous unit. It is detected by the accumulation of inflammatory papules, pustules, nodules, and cysts, as well as non-inflammatory comedones. Dendritic cells, natural killer cells, activated T cells, and B cells are the sole cells that express CD70, a member of the TNF family. The ligand for CD27. The dysregulation of CD27-CD70 complex signaling contributes to the pathogenesis of various immune-related illnesses; thus, investigating the gene expression of CD70 may be advantageous for understanding and managing acne vulgaris. Objective: The current study assessed the gene expression of tissue CD70 in AV patients and correlate the gene expression with disease severity. Conclusions: Lesional CD70 gene expression showed significant ability to predict acne vulgaris. Lesional CD70 gene expression is a novel candidate to be studied in acne pathogenesis.