Kalyan Munde✉(Grant Medical College and Sir Jamshedjee Jeejeebhoy Group of Hospitals)Sandip Ghoti(Grant Medical College and Sir Jamshedjee Jeejeebhoy Group of Hospitals)Vighnesh Rane(Grant Medical College and Sir Jamshedjee Jeejeebhoy Group of Hospitals)Anant Munde(Grant Medical College and Sir Jamshedjee Jeejeebhoy Group of Hospitals)Samkit Mutha(Grant Medical College and Sir Jamshedjee Jeejeebhoy Group of Hospitals)Jaykrishna Niari(Grant Medical College and Sir Jamshedjee Jeejeebhoy Group of Hospitals)Hariom Kolapkar(Grant Medical College and Sir Jamshedjee Jeejeebhoy Group of Hospitals)Ankur Gupta(Grant Medical College and Sir Jamshedjee Jeejeebhoy Group of Hospitals)Gaurav Kothari(Grant Medical College and Sir Jamshedjee Jeejeebhoy Group of Hospitals)Vaishali Gaba(Grant Medical College and Sir Jamshedjee Jeejeebhoy Group of Hospitals)Prasad Jain(Grant Medical College and Sir Jamshedjee Jeejeebhoy Group of Hospitals)Divya Kantak(Grant Medical College and Sir Jamshedjee Jeejeebhoy Group of Hospitals)Suvarna Thorat(Grant Medical College and Sir Jamshedjee Jeejeebhoy Group of Hospitals)
Marfan syndrome (MFS) is a systemic connective tissue disorder primarily caused by mutations in the FBN1 gene, leading to widespread involvement of the cardiovascular, musculoskeletal, and ocular systems. Cardiovascular manifestations, especially aortic root dilatation and dissection, are the major contributors to morbidity and mortality. While valvular involvement such as mitral valve prolapse is relatively common, congenital heart defects like atrial septal defects (ASDs) are extremely rare in MFS and are not part of the diagnostic Ghent criteria. Limited literature exists on this association, especially in early childhood, raising questions about whether this is a coincidental finding or an underrecognized cardiac manifestation.
