Evaluation of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, mean platelet volume, CRP and ESR with disease severity in patients with alopecia areata

Abstract

Background: Alopecia areata (AA) is an autoimmune and inflammatory disease that usually affects the scalp, bearded area, eyebrows, eyelashes, and other hairy areas of the body. It is mostly diagnosed clinically based on clinical history, physical examination, and trichoscopy. In recent years, novel inflammatory markers derived from hematological tests have been introduced. Objective: To evaluate the relationship of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, mean platelet volume, ESR, and C-reactive protein with the severity of alopecia areata. Methodology: A total of 50 patients with AA were included in group A and another 50 healthy individuals were included in group B according to inclusion & exclusion criteria after getting informed written consent. The severity of AA was evaluated by the SALT score. Result: The mean age of the AA patients was 26.96±6.09 years, wherein the maximum patients were aged between 21-30 years. AA patients had significantly higher mean platelet volume (10.75±1.55 vs 10.16±1.20 fL, p=0.036,