Synthesis, characterization, and release behavior of chitosan-coated liposomes carvacrol and cinnamaldehyde in simulated gastrointestinal fluids

Abstract

This study aimed to synthesize chitosan coated liposomes for the encapsulation of carvacrol and cinnamaldehyde, for enhanced stability and sustained release in gastrointestinal fluids. Firstly, the liposomes encapsulated carvacrol and cinnamaldehyde were prepared using the thin-film hydration method and subsequently coated with chitosan to improve their acid-resistant properties. Particle size and encapsulation effectiveness were used to describe the formulations. To determine the stability and release of both compounds under gastrointestinal conditions, their release pattern was assessed in simulated gastric fluid (SGF) and simulated intestinal fluid, simultaneously. The prepared formulation enables these phytoingradients suitable for oral delivery with enhanced stability and sustained release profiles.