Pulmonary artery pressure to stroke volume ratio predicts clinical outcomes in hemodynamically stable acute pulmonary embolism

Abstract

Background: Acute pulmonary embolism (PE) carries substantial risk of hemodynamic compromise, yet existing clinical scores incompletely capture right‑to‑left ventricular interactions. We investigated whether the ratio of pulmonary artery systolic pressure to left ventricular stroke volume (PASP/LVSV), measured within 24 hours of diagnosis, predicts adverse short‑ and mid‑term outcomes in hemodynamically stable PE patients. Methods: In this prospective, multicenter cohort study, 150 patients with confirmed acute PE underwent standardized transthoracic echocardiography within 24 hours of admission. PASP was estimated from tricuspid regurgitant jet velocity and inferred right atrial pressure, while LVSV was calculated from LV outflow tract area and Doppler velocity time integral. Patients were dichotomized into PASP/LVSV