Formulation and evaluation of a chocolate based drug delivery system of Niclosamide

Abstract

The aim of this investigation was to develop an oral chocolate-based drug delivery system for the paediatric population for addressing worm infestation in children. By using the heating and congealing method, specific proportions of the drug and additives were integrated into the chocolate base. Evaluation parameters included various aspects such as appearance, texture, viscosity, hardness, weight variation test, drug content, disintegration, bloom test, melting point and drug release test. Findings indicated favourable physical qualities, appropriate rheological properties, efficient drug release, excellent melting point and negligible bloom. Overall, the developed chocolate-based drug delivery system demonstrated promising qualities for oral use in the paediatric population, suggesting its potential as a dependable and safe oral dosage for managing worm infestation in children.