Silk sericin: A versatile material for tissue engineering and drug delivery

Abstract

Silk sericin, a natural protein derived from the cocoon of the silkworm (Bombyx mori), has emerged as a valuable biomaterial in the fields of tissue engineering and drug delivery. Once considered a by-product of the silk industry, sericin is now recognized for its excellent biocompatibility, biodegradability, and functional versatility. Its inherent ability to support cell growth, stimulate collagen production, and promote wound healing has enabled its application in the development of scaffolds, hydrogels, and skin substitutes. In drug delivery, sericin offers promising features such as pH responsiveness, amphiphilic character, and functional groups that allow for targeted and controlled release of therapeutic agents. Various formulations, including sericin-based nanoparticles and injectable gels, have shown significant potential in treating burns, neurodegenerative diseases, and even diabetes. With its ability to be blended with other polymers and its approval by regulatory bodies, sericin stands out as a sustainable and cost-effective material for biomedical innovation.