Evaluation of prothrombin and activated partial thromboplastin time in dogs with disseminated intravascular coagulation

Abstract

The coagulation profile testing plays a major role in diagnosing disseminated intravascular Coagulation (DIC) in dogs. The aim of this study is to assess the changes in Prothrombin time (PT) and activated partial thromboplastin time (aPTT) in dogs with DIC affected with various diseases such as Haemoprotozoan diseases, Pyometra, Leptospirosis, Neoplasia and others. The PT and aPTT recorded was 8.2±1.2 sec and 25±1.5 sec in healthy (N=10), 12.98±1.66 sec and 132.11±26.79 sec in Haemoprotozoan diseases (N=15), 8.2±0.5 sec and 62±12.34 sec in Pyometra (N=3), 13.6±5.2 sec and 73.7±8 in Leptospirosis (N=2), 75.28±41.47 sec and 258.32±120.57 sec in Neoplasia (N=5), 17.35±2.98 sec and 67.56±26.05 sec in others (N=3) respectively. This study showed that 46% of the dogs with DIC had prolonged PT and 92% had prolonged aPTT.