Bifenthrin-induced alterations in liver and brain biochemical markers of zebrafish, Danio rerio

Abstract

Bifenthrin is a synthetic pyrethroid that affects the enzyme system in living things and causes oxidative stress by producing free radicals and changing oxygen or antioxidant free radicals. Synthetic pyrethroids are the source of pollution and are utilized globally for household, agricultural, and other applications. It has detrimental effects on humans, insects, and aquatic life in many ways. The purpose of the current study was to examine how exposure to Bifenthrin affected the antioxidant enzymes Catalase (CAT), Reduced Glutathione (GSH), and Lipid Peroxidation (LPO) in the liver and brain of Danio rerio during the course of 5,10,15 and 20 days length of exposure. Adult fish were given four different concentrations of bifenthrin for this study: 0.47, 0.93, 1.39, and 1.86µg/l (20%, 40%, 60%, and 80% of the sublethal dose of 96-h LC50). After being exposed to Bifenthrin, Zebrafish, Danio rerio, showed oxidative stress in their liver and brains, as evidenced by a marked dose- and time-dependent decrease in the activity of the enzymes CAT and GSH and an increase in LPO.