Calendula and aloe Vera in wound healing: A review

Abstract

Introduction: Calendula and Aloe vera contain valuable metabolites due to their anti-inflammatory properties and ability to stimulate fibroblasts, supporting their use in medicine. Objective: To analyze the literature regarding key aspects of wound healing, with an emphasis on Calendula and Aloe vera. Methodology: The search was conducted in PubMed and Google Scholar using the terms "Calendula","Aloe vera", "wound healing", "bacteria", "inflammation," combined with the Boolean operators OR and AND. Results: Wound management requires proper assessment, cleaning, disinfection, and debridement to prevent infections, provided the patient follows treatment and aftercare. The skin microbiota, which varies depending on anatomical location and environment, changes in acute wounds (thermophilic bacteria) and chronic wounds (anaerobes), affecting healing. Its study is crucial for clinical management. Calendula officinalis and Aloe vera are plants with anti-inflammatory, antiseptic, and wound-healing properties, supported by their historical use in both traditional and modern medicine. Calendula officinalis exhibits anti-inflammatory, antimicrobial, wound-healing, and antioxidant properties, backed by scientific studies demonstrating its efficacy in wound care and inflammation, establishing it as a promising therapeutic agent in natural medicine. Aloe vera accelerates healing by stimulating cell proliferation, collagen synthesis, and reducing inflammation, though results vary. Its components inhibit pro-inflammatory cytokines and protect keratinocytes, supporting its use in dermatology. Its therapeutic potential lies in its anti-inflammatory and regenerative capabilities. Conclusions: Effective wound care requires proper management and microbiota study, with Calendula officinalis and Aloe vera offering proven anti-inflammatory, antimicrobial, and healing benefits. These natural treatments are valuable in dermatology but need more research for optimal use.