Evaluation of vitamin D status and its effectiveness among patients with Hashimoto’s thyroiditis in Basrah city of Iraq

Abstract

Background: Vitamin D plays a crucial role in immune regulation and hormonal functions, with its deficiency linked to the development of autoimmune diseases, including Hashimoto’s thyroiditis. Aims of the study: Evaluate Vitamin D levels among patients with Hashimoto’s thyroiditis in Basrah City, Iraq, and assess its impact on disease progression and treatment response. Methodology: This case-control study was conducted at Faiha Specialized Diabetes, Endocrine and Metabolism Center, Basrah, in 2024 to assess the relationship between vitamin D, TSH, and anti-TPO Ab in Hashimoto’s thyroiditis patients. Sixty-two patients and 62 controls were included. Patients with low vitamin D received supplementation or no treatment. Blood samples were analyzed using ECLIA before and after an 8-week intervention. Result: Clinical characteristics of 62 Hashimoto’s patients and 62 controls showed no significant differences in age, BMI, gender, or smoking. Vitamin D levels were significantly lower in Hashimoto’s patients (15.1±0.3 ng/mL) vs. controls (36.4±0.6 ng/mL, p