Outcome of Hodgkin lymphoma among children in Bangladesh Shishu hospital, Dhaka, Bangladesh

Abstract

Background: Staging has an important for the prognosis of Hodgkin lymphoma (HL) and choosing the best treatment protocol. This study was designed to evaluate the features of HL and estimate the survival rate in patients got admitted to Bangladesh Shishu Hospital & Institute (BSH&I) for diagnosis and treatment. Methods: Total 40 patients <18 years of age diagnosed with HL at BSH&I from January 2018 to 2024 were enrolled. Staging, demographic findings, treatment protocols and outcomes were studied and analyzed for possible correlation between various parameters. Results: In our study, the mean age of patients was 9.9 years (SD±3.8), and included 60% (n 18) male and 40% (n 12) female patients. Fifty percent of patients were treated with ABVD protocol and 50% with BEACOPP protocol. There was a significant association between coughing as a symptom and high stage of the disease (p 0.042). The 5-year event-free survival (EFS) and overall survival (OS) rate for patients in low-risk group were better than intermediate and high-risk group. Conclusion: Treatment modalities based on staging is important for improving outcomes in HL. In the limited settings, ABVD and other treatment protocols supplemented with BMT in relapsed cases is associated with good outcomes.