Evaluating MicroRNA as diagnostic indicators in recurrent miscarriage: A review

Abstract

Miscarriage is the most common pregnancy problem, and its etiology and pathogenesis are still unclear. New screening biomarkers that would enable the early detection of conditions linked to pregnancy pathology are constantly being sought for. One interesting area of research that may aid in determining the prognostic indicators for pregnancy disorders is the profiling of miRNA expression. MicroRNA molecules are involved in a number of processes that are essential to the body's growth and operation. These include the reaction to oxidative stress, blood vessel development or cancer, programmed cell death, and cell division and differentiation. Because microRNAs can control post-transcriptional gene expression, they have an impact on the quantity of distinct proteins in the body and maintain the regular operation of numerous cellular functions. This publication provides an overview of the function of microRNA molecules in the miscarriage process based on the scientific data currently available. In addition to being an evaluation factor in the clinical care of women in the initial stages of pregnancy, especially after their first miscarriage, the development of putative the microRNA molecules as early low-risk diagnostic indicators may be evaluated as soon as the initial stages of pregnancy. In conclusion, the scientific findings presented here established a new line of inquiry for the advancement of prognostic monitoring during pregnancy and preventative care.