Pharmacodynamic study of traditional medicament used as an aphrodisiac by the population from greater Libreville, Gabon

Abstract

The use of traditional herbal products as a solution to improve sexual life would represent a danger for consumers such as several secondary effects on the human body. This study aims to verify the aphrodisiac effects attributed to a traditional recipe used by populations in Gabon. Phytochemical analyses and the aphrodisiac effect was evaluated using the classic methods of laboratory with minor modifications. Viagra was used as a reference molecule. Acute toxicity in rats in vivo was evaluated only for the aqueous extract by determining the LD50. Phytochemical analysis of different extracts revealed an abundance of secondary metabolites. Pharmacodynamic tests showed a change in sexual activity in Wistar rats of total extracts. The toxicity test of the recipe showed a mortality of rats at the respective doses of 4000 mg /kg and 5000 mg /kg with a low toxicity. The results obtained show an aphrodisiac and low toxicity.