Lipid-lowering and antioxidant potentials of mixed aqueous extracts of Piper guineense and Vernonia amygdalina in Alloxan-induced diabetic rat model

Abstract

Background and Objective: Diabetes mellitus is a metabolic disorder with severe cardiovascular complications. Given the limitations of conventional treatments, alternative therapies are essential. This study evaluated the hypoglycemic, lipid-lowering and antioxidant effects of mixed aqueous extracts of Piper guineense and Vernonia amygdalina in alloxan-induced hyperglycemic rat models. Methods: Thirty male Wistar rats were randomly divided into five groups (n = 6 per group): Control, Negative control, Positive control, 200 mg/kg and 400 mg/kg of the mixed extract for 21 days. The Fasting blood glucose levels were measured before inducement, before treatment and before sacrifice of the rats. GraphPad prism 10.2 was used for the statistical analysis with significance at p