Efficacy of platelet-rich plasma (PRP) therapy in tendon and ligament healing

Abstract

Platelet-rich plasma (PRP) therapy has emerged a promising biological treatment for enhancing tendon and ligament healing offering a minimally invasive approach to tissue regeneration PRP is an autologous blood product that concentrates platelets and growth factors. Which are critical for tissue repair and regeneration, this review aims to comprehensively evaluate the efficacy of PRP therapy in promoting tendon and ligament repair highlighting its mechanisms of action clinical applications limitations and future directions. The methodology involved a systematic search of recent clinical trials meta-analyses and experimental studies published in peer-reviewed journals, Data extraction focused on key outcomes such as pain reduction, functional recovery and structural improvement in injured tissues,` Additionally variations in PRP preparation protocols and their impact on therapeutic outcomes were analyzed. The result demonstrate` that PRP therapy significantly reduces pain, with Visual Analog Scale (VAS) scores decreasing from 7.2±1.3 at baseline to 1.9±0.7 at six months post-treatment (p