Sustainable UV spectrophotometric assay method development and validation of chlorpheniramine hydrochloride in tablet dosage form

Abstract

With growing attention to environmental sustainability in analytical sciences, this study presents an eco-friendly UV spectrophotometric method for Chlorpheniramine maleate. This method is simple, precise, accurate, reproducible, eco-friendly as well as sensitive. The method has been optimized and validated using Water as a diluent, shows no interference. UV-Visible model 1800 was used for the analysis and maximum absorbance (λmax) measured at 223 nm against blank solution. Important validation parameters validated. Results show high accuracy with recovery between 95% to 105% and precision with an RSD below 1.0% across multiple trials. The linearity noticed between the concentration range i.e. 8-24 µg/ml with correlation coefficient in limit. This eco-friendly method demonstrates reliability for routine regular analysis in pharmaceutical industries in Quality Control, stability while reducing environmental impact.