Regulation of different zinc sources on salmonella challenged broilers and ITS mechanism

Abstract

Zinc is a crucial micronutrient that significantly influences the health and performance of broilers, particularly in the context of Salmonella infections. This review examines the effects of various zinc sources-namely inorganic, organic, and natural forms-on Salmonella-challenged broilers, highlighting their roles in immune function, gut health, and oxidative stress reduction. Inorganic zinc sources, such as zinc oxide and zinc sulfate, are commonly used but may have lower bioavailability compared to organic sources like zinc amino acid chelates. The mechanisms by which zinc exerts its effects include modulation of immune cell activity, enhancement of intestinal barrier integrity, regulation of gene expression related to immune responses, and activation of key cellular signaling pathways. Additionally, the interaction between zinc and dietary phytates can affect its absorption and utilization. Understanding these dynamics is essential for optimizing nutritional strategies to improve resistance against Salmonella in poultry production. This review underscores the importance of selecting appropriate zinc sources to enhance the health and productivity of broilers under pathogen challenge conditions.