Phytochemical profiling, antioxidant activity and Antitumor activity of Eryngium foetidum leaves extract against Ehrlich ascites carcinoma (EAC) cell line

Abstract

Eryngium foetidum is a well-known medicinal plant and its leaf is commonly used as food. This study was conducted to investigate the Phytochemical profiling, antioxidant activity and anticancer activity of Eryngium foetidum leaves against the Ehrlich Ascites Carcinoma (EAC) cell line in Swiss albino mice. The anticancer efficiency of Eryngium foetidum leaves methanolic extract (EFLME) was assessed in Swiss albino mice bearing EAC cells, with the extract administered at doses of 25, and 50 mg/kg body weight/day. This study also investigates the total phenolic, total flavonoid, total flavonol and antioxidant activity by total antioxidant capacity compared to ascorbic acid. We also evaluate the free radical scavenging assays of EFLME using DPPH and ABTS, with Ascorbic Acid as a standard. Eryngium foetidum leaves exhibit promising antitumor activity, inhibiting EAC cell growth by 34.27±7.78% and 58.45±4.36% at doses of 25, and 50 mg/kg body weight/day, respectively, compared to control EAC-bearing mice. The result of the DPPH and ABTS assay indicated notable antioxidant activity. Our work showed that a variety of bioactive phytonutrients with potent antioxidant activity and growth-inhibiting effects against EAC cell lines are naturally present in Eryngium foetidum leaves.