Role of LH level on ICSI outcome in women with PCOS Undergoing GnRh antagonist stimulation

Abstract

Background: Polycystic Ovary Syndrome (PCOS) impairs fertility through hyperandrogenemia, insulin resistance, and elevated LH/FSH ratios, affecting oocyte quality and implantation. This study investigates the impact of serum LH levels on IVF/ICSI outcomes, including pregnancy and live birth rates. Aim of study is to Explore the Influence of LH Levels on IVF/ICSI Outcomes in Women with PCOS Undergoing GnRH-Antagonist Stimulation Protocol. Methods: Ninety IVF/ICSI patients with PCOS undergoing GnRH-antagonist protocols were divided into groups based on basal LH (bLH), trigger-day LH (hLH), and hLH/bLH ratio. Relationships between LH levels and outcomes like oocytes retrieved, pregnancy rates, and live birth rates were analyzed. Secondary factors included fertilization rates, top-quality embryos, and total Gn dose. Results: No significant differences were found among groups based on bLH levels, but lower hLH (≤2 mIU/mL) was associated with reduced basal FSH and LH levels. Patients with hLH/bLH ≤ 0.5 had higher clinical pregnancy rates, while those with hLH/bLH ≥ 1 had better top-quality embryo rates. Conclusion: The study identified the hLH/bLH ratio as a potential predictor of the impact of LH levels on embryo development potential and pregnancy outcomes in women with PCOS undergoing GnRH-antagonist stimulation cycles.