Correlation of homocysteine with insulin resistance and ß-cell function among patients with polycystic ovary syndrome

Abstract

Background: The most prevalent endocrinopathy in women, polycystic ovarian syndrome (PCOS), affects 7% to 12% of women globally who are of reproductive age. Numerous clinical symptoms, including obesity and insulin resistance (IR), might be signs of PCOS. Women who have PCOS have been found to have hyperhomocysteinemia (HHcy). Objective: To study the correlation of homocysteine (Hcy) level with IR and ß-cell function among women with PCOS. Methods: One hundred women with PCOS and one hundred control women participated in a case-control research. Blood pressure, body mass index, waist circumference, insulin, glycated haemoglobin (HbA1c), plasma Hcy, fasting blood glucose (FBG), testosterone, and body mass index (BMI) were all measured. In addition, IR and pancreatic ß-cell function were determined using HOMA-IR and HOMA-B equations respectively. Results: Patients with PCOS had significantly greater levels of Hcy, FBG, insulin, HOMA-IR, HOMA-B, testosterone (p