Cytotoxicity and antimicrobial efficiency of gold (Au) nanoparticles formulated by green approach using Dioscorea pubera blume tuber extract

Abstract

Synthesis of ultrafine particles using green chemistry has been popular owing to the exciting properties and innovative applications of these nanostructures. Novel, cost-effective, and eco-friendly gold nanoparticles (Au NPs) were synthesized using tuber extract of D.pubera(DP-AuNP). The synthesized AuNPs were characterized by UV-visible spectroscopy, Fourier transform infrared spectroscopy, EDAX, scanning, and transmission electron microscopy. In addition, antibacterial, and cytotoxicity properties of Au NPs were studied. The cytotoxicity of the synthesized DP-Au NPs was evaluated using an MTT assay on lung (NCIH-460), cancer cells. The synthesized AuNPs exhibited moderate antibacterial activity against the bacterial strains used. Synthesized AuNPs have great cell viability in a dose depended manner and demonstrate that this method for synthesis Gold nanoparticles provided nontoxic. Based on the investigation, the study inferred that DP-AuNPs are therapeutic in combating human pathogens.