Effects of Platelet Rich Plasma (PRP) on the recovery of gastrocnemius muscle rupture in Wistar straining white rats

Abstract

Gastrocnemius muscle rupture is a lower extremity rupture that has a poor prognose. Rupture of the gastrocnemius muscle can interfere the body's weight-bearing ability. Rupture are especially common among athletes and individuals who engage in activities that sudden involve and forceful movements of the calf. The current treatment has not been able to restore the biological and mechanical properties of the muscles to their original condition. One of the treatments used to speed up the healing of the gastrocnemius muscle is application of PRP. Objective: To determine the effect Platelet Rich Plasma (PRP) on the recovery of muscle rupture in animals model (wistar strain white rats). Methods: This is an experimental study with a post-test only control group design using animals model (white rats). This study was conducted at the INA Lab Laboratory, Padang in November 2024. The samples were divided into two groups, the treatment group and the control group where both of these groups were injured and sutured to the muscle. The control group was not given PRP, while the treatment group was given 0.1 cc of PRP. The PRP used was heterologous from healthy human blood. Observations were made after 1 week both groups were maintained and treated. Results: There were 12 white rats which were divided into the PRP group and the control group. The PRP group had a lower histopathological score (7.68) than the control group (15.99). In this study, there was a significant difference between the recovery of muscle ruptures in animal model (white rats) that were given Human Platelet Rich Plasma (PRP) and experimental animals (rats) that were not given PRP (p value 0.001). Conclusion: PRP improves healing in Gastrocnemius muscle rupture.