Correlation between smoking behaviour and surgical site infection on grade III colorectal cancer patients following elective colectomy

Abstract

Introduction: Colorectal cancer is an accumulation of genetic mutation promoting excess proliferation of cells and inactivation of tumor suppressor genes causing neoplastic lesion and polyps to form on the colon and rectal epitelium. Smoking is one of the many risk factors which increases the risk of not only colorectal cancer formation but also post colectomy complications because of its carcinogenic components and wound healing disrupting properties. This study was done to determine the correlation between smoking behaviour and surgical site infection on grade III colorectal cancer patients following elective elective colectomy. Method: This study is an analytic observational study with a retrospective cohort design. Data was collected by conducting an interview with patients undergoing treatment and from medical records in dr. Moewardi General Hospital with a total of 40 samples divided into 2 groups, 20 samples as the case group (smoker) and 20 samples as the control group (non-smoker). Data analysis was done using the fisher’s exact test to evaluate correlation between age, gender, smoking status and smoking intensity with post-colectomy surgical site infection. Result: The study did not find correlation between between age, gender, smoking status and smoking intensity with post-colectomy surgical site infection (p-value = 1.000; 0.677; 0.407; 0.219). Conclusion: Smoking behavior did not influence the risk of post-colectomy surgical site infection.