Innovation and testing of domperidone and ondansetron medicated jelly formulation

Abstract

The objective of this investigation was to developed and assess and oral jelly containing domperidone and ondansetron for addressing nausea and vomiting in pediatric patients. Through the application of heating and congealing method, specific proportions of active compounds and additives were integrated into the jelly formulation. Preformulation examinations were conducted to evaluate both the physical and chemical characteristics, while the evaluation criteria encompassed various aspects such as the appearance, texture, spread ability, viscosity, ph level, uniformity of content, in vitro dissolution and stability over a three month period. Findings indicated favorable physical attributes, consistent drug content, suitable ph levels, non adhesive texture, excellent spread ability, appropriate rheological properties, efficient drug release and stability without notable alteration in appearance, ph or drug content over the designated time frame. Overall, the developed medicated jelly demonstrated promising qualities for pediatric application, suggesting it’s potential as a dependable and safe oral dosage for managing nausea and vomiting in children.