Calprotectin in Dermatology

Abstract

Calprotectin represents a potential biomarker of inflammation that may forecast a serological relapse prior to a clinical one in many inflammatory disorders. It is released by myeloid cells, including neutrophils, monocytes, as well as macrophages, but lymphocytes and basophils do not express calprotectin. Calprotectin is proposed as an inflammatory marker, a component of defensive mechanisms, and a regulator of the immune system's physiological processes. It is aberrantly expressed in the epidermis in some inflammatory hyperproliferative conditions and during wound healing, whereas increased serum calprotectin levels could be identified in inflammatory diseases as well as autoimmune responses.