Role of calprotectin in dermatology

Abstract

Two proteins, S100A8 and S100A9, combine to form the heterodimer known as calprotectin. Activated monocytes and neutrophils in the bloodstream and in inflammatory tissues are the primary producers of this protein. Calprotectin may play a part in inflammatory situations because it was found to have a cytokine-like activity in addition to its bacteriostatic function. It plays a role in controlling how inflammatory cells adhere to the endothelium. While higher blood calprotectin levels can be found in inflammatory illnesses and autoimmune reactions, it is aberrantly produced in the epidermis in some inflammatory hyperproliferative situations and during wound healing.