Evaluation of Datura metel seed extract as local anaesthetic agents for orchidectomy in West African dwarf buck goats

Abstract

This study investigates the local anesthetic potential of Datura metel seed extract in West African Dwarf (WAD) Buck Goats, compared to standard lidocaine, specifically for orchidectomy procedures. Datura metel is recognized for its various therapeutic uses, including anesthetic properties attributed to its tropane alkaloids. Twenty adult WAD Buck Goats were divided into two groups for subcutaneous administration of either Datura metel extract (75 mg/kg body weight) or lidocaine hydrochloride (4 mg/kg body weight). The effects on anesthesia onset, duration, and percentage were evaluated through negative twitch response assessments and hematological analyses at specified intervals. Results indicate that Datura metel provided effective analgesia with an onset time of 15.80±0.16 minutes and a duration of 35.95±0.18 minutes, significantly longer and shorter, respectively, compared to lidocaine (onset: 3.20±0.02 minutes; duration: 56.50±0.10 minutes). The percentage of anesthesia was also significantly lower with Datura metel (46.6±1.20%) than with lidocaine (93.3±0.21%). No significant changes in vital physiological parameters were observed, suggesting compatibility. Findings highlight Datura metel’s potential as a local anesthetic, yet its limitations in efficacy and duration assert the necessity for careful application, particularly for minor surgical procedures. Further studies are recommended to isolate the active components responsible for the anesthetic effects to enhance its application and safety profile in veterinary medicine.